Biotransformation of furanocoumarins by Cunninghamella elegans

Biotransformation of furanocoumarins by Cunninghamella elegans

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Biotransformation of Furanocoumarins; psoralen (1), bergapten (2), xanthotoxin (3) and imperatorin (4) was explored by neutral checkered phone case Cunninghamella elegans NRRL 1392, revealing the metabolism of psoralen (1) and bergapten (2) into bergaptol (5), while xanthotoxin (3) and imperatorin (4) were converted into xanthotoxol (6).On the other hand unexpected conversion of xanthotoxin (3) into 3,4 dihydroxanthotoxin (7) occurred.The structure of the isolated pure metabolites was established using physical and spectroscopic techniques including, melting points, IR, 1H sal manaro knives NMR, 13C NMR and mass spectroscopy.